Basic Information
VIS ID
TVIS44022455
Fusion event
HTLV-1-MROH2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
41054757/41054655 (Hg38)
End
41054757/41054655 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
MROH2B
Nearest miRNA
hsa-mir-10397/Upstream/2497094; hsa-mir-103a-1/Downstream/12896849;
Nearest TSS
ENST00000502646/Upstream/3098; ENST00000505931/Downstream/3551;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/218884, chr5-CpG: 26/Downstream/455026
Upstream sequence
TCTTTTCACTGAGACGTCCTTTAGCTGTGTGTACTTTAGGCCTCTACCTTGATGAAGTTTATCTCTTTGGAAAAGATGGAGTTCTTTTAAAAATGGAATT
Downstream sequence
GACCACAGAGTTCTTTATAAAATAGTCTCATAAGTAGATCCTTAAAGAATCAAAATAATTTCATTCATTCTTAAAGCTACCATCGACAAGAGTTTCTATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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