Basic Information
VIS ID
TVIS44022458
Fusion event
HTLV-1-OXCT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
41815616/41815514 (Hg38)
End
41815616/41815514 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
OXCT1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-26b-5p ; hsa-mir-100-5p
Nearest miRNA
hsa-mir-10397/Upstream/3257953; hsa-mir-103a-1/Downstream/12135990;
Nearest TSS
ENST00000502646/Upstream/20871; ENST00000505931/Downstream/27243;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/304965, chr5-CpG: 104/Downstream/54047
Upstream sequence
gagattctccagcctcagcctcctgagcagctgggattacaggcatgcaccactatgcccagcTGCTAACATTTTTTGTTTGCCCAGAAATGCCAATCTT
Downstream sequence
CTCTTTATGTGTGACTTAATAACATTCAGGCAATATTCTAAATATCTATATTTCATTTGTCATATCTCTTTTAAAAAAGAAATTTTATTAGGACTGTGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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