Basic Information
VIS ID
TVIS44022463
Fusion event
HTLV-1-PARP8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
50110642/50814808 (Hg38)
End
50110642/50814808 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
PARP8
miRNAs that regulate target gene
hsa-mir-145-5p
Nearest miRNA
hsa-mir-10397/Upstream/12257247; hsa-mir-103a-1/Downstream/3136696;
Nearest TSS
ENST00000502646/Upstream/146915; ENST00000508923/Downstream/45212;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/146865, chr5-CpG: 53/Downstream/154443
Upstream sequence
TGCCTTTTGTCTGCTGTGCAGAGGCACCGTGGATTGCATCGTGTTAGGCTTCATCAGCTACCTAATGCAATGTAACTTGGGAGATAAGATAAATCAGAGG
Downstream sequence
AATGACACTGTATTAGATTTGAAAGATGAGAGCTCTTCCAAAGTAATTGCAGAGTGTATATTTCAGTGCTGTTGACTTCATGAGGTTATAGAAGTCAATA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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