Basic Information
VIS ID
TVIS44022489
Fusion event
HTLV-1-MCCC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
70947470/71651643 (Hg38)
End
70947470/71651643 (Hg38)
Orient
+
Location type
Intronic
Target gene
MCCC2
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-769-5p ; hsa-mir-6864-3p ; hsa-mir-3606-5p ; hsa-mir-3672 ; hsa-mir-661 ; hsa-mir-4786-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-4714-3p ; hsa-mir-1244 ; hsa-mir-199a-3p ; hsa-mir-199b-3p ; hsa-mir-222-5p ; hsa-mir-3129-5p ; hsa-mir-3614-5p ; hsa-mir-6500-3p ; hsa-mir-936
Nearest miRNA
hsa-mir-10397/Upstream/11947940; hsa-mir-103a-1/Downstream/517824;
Nearest TSS
ENST00000502646/Upstream/24989; ENST00000296777/Downstream/67520;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/64057, chr5-CpG: 63/Downstream/67447
Upstream sequence
TGGAGGGAGCCCTGTCTGCTCTGTGCAGGAATCATCAGGTCTTCCACCTAGATTGTGGAGTGAGGTACTGCCTCCCTGAATGCATCCATCCATGCCTCAC
Downstream sequence
ATCCCTAGTTGTCTTTTCCAAGCACTCGGAACTCTGGAGACTTACATTGAGGTTTCAGATTCACTTTAGTACCTACTAGTATCAAAGGAAACAGATAGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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