Basic Information
VIS ID
TVIS44022493
Fusion event
HTLV-1-HOMER1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
78796847/79501024 (Hg38)
End
78796847/79501024 (Hg38)
Orient
-
Location type
Intronic
Target gene
HOMER1
miRNAs that regulate target gene
hsa-let-7d-5p ; hsa-mir-484 ; hsa-mir-129-5p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-4272 ; hsa-mir-6074 ; hsa-mir-19b-3p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-10397/Upstream/6622361; hsa-mir-103a-1/Downstream/3339131;
Nearest TSS
ENST00000502646/Upstream/103114; ENST00000502269/Downstream/11770;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/263352, chr5-CpG: 112/Downstream/12500
Upstream sequence
ATTtgtgtgtgtgtgtgtgtgtgtgtgtgAGacagacagacacacacacacacacacacacacacacacaAggtctggctctattacccaggctgcagtg
Downstream sequence
cagtggcaggatctcagcttactgcatcctctgcctcccaggctcaagccatcctcccaccttggcctccccagtagctgggactacagatgtgtaccac
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate