Basic Information
VIS ID
TVIS44022497
Fusion event
HTLV-1-VCAN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.2
Reference genome
GRCh37/hg19
Start
82768517/83472698 (Hg38)
End
82768517/83472698 (Hg38)
Orient
+
Location type
Intronic
Target gene
VCAN
miRNAs that regulate target gene
hsa-mir-545-3p ; hsa-mir-5197-3p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-218-5p ; hsa-mir-578 ; hsa-mir-3185 ; hsa-mir-643 ; hsa-mir-335-3p ; hsa-mir-4436b-5p ; hsa-mir-627-3p ; hsa-mir-6777-3p ; hsa-mir-5003-3p ; hsa-mir-23b-3p ; hsa-mir-129-5p ; hsa-mir-302c-5p ; hsa-mir-361-3p ; hsa-mir-3680-3p ; hsa-mir-450b-5p ; hsa-mir-4666b ; hsa-mir-5011-3p ; hsa-mir-507 ; hsa-mir-552-5p ; hsa-mir-557
Nearest miRNA
hsa-mir-10397/Upstream/632474; hsa-mir-103a-1/Downstream/3642181;
Nearest TSS
ENST00000502646/Upstream/773; ENST00000515397/Downstream/39404;
Nearest CpG islands
chr5-CpG: 61/Target, None/Upstream, None/Downstream
Upstream sequence
GCGCGGACCTGACCCCTTCAGACCGCAGGCAGTCTGGGAGGAGGTCCGGCCGGGGGAGGTGCAGGATCCCCGCCGTGTCTCTTTGACGACTTGGGGACTG
Downstream sequence
TCACGGTTCTCTCCCGGCGCCCCTGGGTTCTTTTGTCCTGCACGCGGTGCGAAGGGGCCAGCAGGGAAGGAGCAGAGGATGGGGGGTGGGGTTGTTGGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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