Basic Information
VIS ID
TVIS44022534
Fusion event
HTLV-1-SAMD5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
148112162/147791026 (Hg38)
End
148112162/147791026 (Hg38)
Orient
-
Location type
Intronic
Target gene
SAMD5
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-145-5p ; hsa-mir-498 ; hsa-mir-6783-3p ; hsa-mir-1343-3p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-4695-3p ; hsa-mir-6787-3p ; hsa-mir-1304-3p ; hsa-mir-6742-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-660-3p ; hsa-mir-6736-3p ; hsa-mir-6890-3p ; hsa-mir-1306-5p ; hsa-mir-4503 ; hsa-mir-6832-3p ; hsa-mir-153-5p ; hsa-mir-6512-5p ; hsa-mir-7109-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3688-3p ; hsa-mir-4443 ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-4738-5p ; hsa-mir-1243 ; hsa-mir-3654 ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-4693-3p ; hsa-mir-3121-5p ; hsa-mir-3190-5p ; hsa-mir-3675-3p ; hsa-mir-3926 ; hsa-mir-4684-5p ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-548as-3p ; hsa-mir-548at-3p ; hsa-mir-548ay-3p ; hsa-mir-548t-3p ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-10398/Upstream/7107143; hsa-mir-1202/Downstream/3311649;
Nearest TSS
ENST00000381078/Upstream/47702; ENST00000367469/Downstream/229948;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/281600, chr6-CpG: 79/Downstream/551263
Nearby gene
SAMD5(+221005) ;
Upstream sequence
atcatgttgactttgtgttaagtattgtgtgtgtatgtaaaaacatccgagatgtcctttctgcacatctgcatctatgaaagataggccgggtgtggtg
Downstream sequence
gctcacgcctgtaatcccagcactttgggaggctggggtgggcggatcacttgaggtcaggagttcgagaccagcctggccaacatggggaaacctcacc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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