Basic Information
VIS ID
TVIS44022540
Fusion event
HTLV-1-AGPAT4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q26
Reference genome
GRCh37/hg19
Start
161552290/161131258 (Hg38)
End
161552290/161131258 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA6E
Target gene
AGPAT4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-877-3p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-6850-3p ; hsa-mir-141-5p ; hsa-mir-6875-3p ; hsa-mir-3682-5p ; hsa-mir-1909-5p ; hsa-mir-4778-3p ; hsa-mir-759 ; hsa-mir-519e-3p ; hsa-mir-515-3p ; hsa-mir-33b-3p ; hsa-mir-4797-5p ; hsa-mir-6750-3p ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6894-3p ; hsa-mir-5001-3p ; hsa-mir-6720-5p ; hsa-mir-4727-5p ; hsa-mir-6512-3p ; hsa-mir-4763-5p ; hsa-mir-20a-3p ; hsa-mir-766-3p ; hsa-mir-6849-3p
Nearest miRNA
hsa-mir-10398/Upstream/2366505; hsa-mir-1913/Downstream/5378096;
Nearest TSS
ENST00000381078/Upstream/22379; ENST00000544266/Downstream/18031;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/138726, chr6-CpG: 76/Downstream/514627
Upstream sequence
AACAAATTAAATGTAAAAATTGTATGACTCTTACCCAGTGAAAAGCTTTACTAACACAGCCCTGGGTGCTATTTCCAGATACTGAAAAGATCTAAGTAGG
Downstream sequence
TGCTTAAGAACTGCTTTTTAACCCATTCACAACCTTCATATTAAACTAGGATGAGGCTGCAGGAGCTGAGGAAGGAAGGCCTGGGTGGGAACCTGGATGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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