Basic Information
VIS ID
TVIS44022546
Fusion event
HTLV-1-WDR27 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q27
Reference genome
GRCh37/hg19
Start
170027919/169627823 (Hg38)
End
170027919/169627823 (Hg38)
Orient
+
Location type
Intronic
Target gene
WDR27
Nearest miRNA
hsa-mir-10398/Upstream/2629911; hsa-mir-4644/Downstream/702938;
Nearest TSS
ENST00000381078/Upstream/200754; ENST00000332290/Downstream/21410;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/50025, chr6-CpG: 25/Downstream/31318
Upstream sequence
GGTTCAGTTGAGATAACCTGACATTTAGATGGTAAGGAGGGAAGAAAAACAGCATCCAGGCAGAGGAACTAGGCAGGCCTGGAGTCCAACTCCCAGCTCA
Downstream sequence
CAGCCCATGCAGAGGGAGGAGGGAGGCCCTGCACTCTGAGTCCTCATCCATCGAATGTCCTCGCTGAGCCTGTGAGAACACACAGGGAAAGGCCACGGCG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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