Basic Information
VIS ID
TVIS44022550
Fusion event
HTLV-1-MBOAT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
20176441/20176210 (Hg38)
End
20176441/20176210 (Hg38)
Orient
+
Location type
Intronic
Target gene
MBOAT1
miRNAs that regulate target gene
hsa-mir-4325 ; hsa-mir-4793-3p ; hsa-mir-7113-3p ; hsa-mir-6752-3p ; hsa-mir-7977 ; hsa-mir-3178 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6499-5p ; hsa-mir-6850-3p
Nearest miRNA
hsa-mir-3691/Upstream/1604330; hsa-mir-10398/Downstream/6971416;
Nearest TSS
ENST00000381078/Upstream/337130; ENST00000449143/Downstream/35877;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/337127, chr6-CpG: 83/Downstream/35827
Upstream sequence
ctgtctctacaaaaagtaaaataattagctgggcatagtgatgtgcacctgtaattccacctactaaggaggcctaggcaggaagattgcttgagctcaa
Downstream sequence
gagttcaaggttacagtgagctgtgattgcaccaccgcagtaaatcctgtgcaacaaagtgagaccctgtctttaaaaaaaaaaaaaTTACAACCTATAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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