Basic Information
VIS ID
TVIS44022561
Fusion event
HTLV-1-GABBR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
29571158/29603381 (Hg38)
End
29571158/29603381 (Hg38)
Orient
+
Location type
UTR3
Target gene
GABBR1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-3143/Upstream/2455693; hsa-mir-10398/Downstream/980951;
Nearest TSS
ENST00000381078/Upstream/15926; ENST00000469353/Downstream/1768;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/49325, chr6-CpG: 55/Downstream/24140
Upstream sequence
GCTTCAAGCCAGGTACGAACTAAATTGTGAAGAGGTGATACAAAATTACATGAAGCAGTAAGAGAGAAAAAGGTCTGTTTCCCAGAGGTATGAGAGACCC
Downstream sequence
AAATCAGCCCAGAACTCACAGGGGGACATGTATTTACAAGAGATGAGATTGGATAGCATGTTCTTCCCAGCTGGGGATGGGGACCCCCTGCTTCCTGAGt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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