Basic Information
VIS ID
TVIS44022567
Fusion event
HTLV-1-ANKS1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
35040879/35073102 (Hg38)
End
35040879/35073102 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
ANKS1A
miRNAs that regulate target gene
hsa-mir-92a-3p ; hsa-mir-487a-5p ; hsa-mir-509-3p ; hsa-mir-487b-5p ; hsa-mir-4781-3p ; hsa-mir-6740-5p ; hsa-mir-744-3p ; hsa-mir-1263 ; hsa-mir-150-3p ; hsa-mir-4777-3p ; hsa-mir-4684-3p ; hsa-mir-622 ; hsa-mir-4307 ; hsa-mir-513a-5p ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3945 ; hsa-mir-6847-3p ; hsa-mir-5196-3p ; hsa-mir-6854-5p ; hsa-mir-1205 ; hsa-mir-125a-3p ; hsa-mir-3197 ; hsa-mir-34a-5p ; hsa-mir-34c-5p ; hsa-mir-3665 ; hsa-mir-4316 ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-4710 ; hsa-mir-548au-3p ; hsa-mir-558 ; hsa-mir-6087 ; hsa-mir-657 ; hsa-mir-6717-5p ; hsa-mir-6765-5p
Nearest miRNA
hsa-mir-1236/Upstream/832366; hsa-mir-10398/Downstream/397406;
Nearest TSS
ENST00000381078/Upstream/14854; ENST00000274938/Downstream/47943;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/183215, chr6-CpG: 75/Downstream/67922
Upstream sequence
ccttggataagtccagtctgctctccaagcctcagtttctttctgtgtaatgtgagcagctcctatctgaaaggtttattgggcggatttttgcaggtca
Downstream sequence
tgggtgtgaagcccctagcacagtgctggactgtggtcagaactcagtaTCACTGGCCCGCATCTTCACTGTGAGCCCAGGACAGGCCACACGTCACACG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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