Basic Information
VIS ID
TVIS44022569
Fusion event
HTLV-1-MDGA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
37664196/37696420 (Hg38)
End
37664196/37696420 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
MDGA1
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-6738-3p ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-18a-3p ; hsa-mir-1237-3p ; hsa-mir-6793-3p ; hsa-mir-8064 ; hsa-mir-8485 ; hsa-mir-3189-5p ; hsa-mir-4758-3p ; hsa-mir-5699-5p ; hsa-mir-324-3p ; hsa-mir-1913
Nearest miRNA
hsa-mir-1236/Upstream/140998; hsa-mir-10398/Downstream/1377894;
Nearest TSS
ENST00000381078/Upstream/32104; ENST00000469208/Downstream/391;
Nearest CpG islands
chr6-CpG: 280/Target, None/Upstream, None/Downstream
Upstream sequence
GCCGGCTCGCCCGCAAGCCGCGCGGCAACTCCGGCTCATGCATCGCTTGGCTTCCACTCCGGAGGCCGAGCCAGGACGAGGTTTCGGTGCAAGTCGCTGC
Downstream sequence
ACCAGTCCTAGACTGGGTCTGTCCGGGTCTCCCGAGCCGACCGGGTGCTCTCAAGGGTTCCTAATCATTCCCACCTCTAGCAGGGTGTGGGAAAGTGGGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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