Basic Information
VIS ID
TVIS44022578
Fusion event
HTLV-1-TFEB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
41674213/41706475 (Hg38)
End
41674213/41706475 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
TFEB
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-29a-3p
Nearest miRNA
hsa-mir-1236/Upstream/107687; hsa-mir-10398/Downstream/27079;
Nearest TSS
ENST00000381078/Upstream/535; ENST00000438967/Downstream/13921;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/22631, chr6-CpG: 164/Downstream/27796
Upstream sequence
CTGGTGGGGGCAGGACGGGGCAGCCAGTGCTGGCAGAGGCCACTAGACAGCACAGGCAGTGGCCCAGGAACTCAGCGGGGGCTCTTCTCCCCTCACAACA
Downstream sequence
CACACCTACACCCACCCCCAACCACCCTTACACCCCCCCACCCCCATCCTGCCCAAGAGTTGGGGTTCTGGGAAGAGCTAACAGGGGCCCACCCCAGGAT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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