Basic Information
VIS ID
TVIS44022583
Fusion event
HTLV-1-ADGRF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
47643540/47675804 (Hg38)
End
47643540/47675804 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRF2
miRNAs that regulate target gene
hsa-mir-1249-5p ; hsa-mir-1252-5p ; hsa-mir-1321 ; hsa-mir-149-3p ; hsa-mir-3185 ; hsa-mir-4419a ; hsa-mir-4476 ; hsa-mir-4510 ; hsa-mir-4533 ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6758-5p ; hsa-mir-6785-5p ; hsa-mir-6797-5p ; hsa-mir-6856-5p ; hsa-mir-6873-5p ; hsa-mir-6876-5p ; hsa-mir-6883-5p ; hsa-mir-9500 ; hsa-mir-1225-3p ; hsa-mir-1233-3p ; hsa-mir-1288-3p ; hsa-mir-18a-5p ; hsa-mir-18b-5p ; hsa-mir-3199 ; hsa-mir-3202 ; hsa-mir-4475 ; hsa-mir-4735-3p ; hsa-mir-4792 ; hsa-mir-4793-3p ; hsa-mir-7515 ; hsa-mir-7703 ; hsa-mir-8052
Nearest miRNA
hsa-mir-10398/Upstream/2478034; hsa-mir-10524/Downstream/4468545;
Nearest TSS
ENST00000381078/Upstream/2433; ENST00000371220/Downstream/10060;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/197449, chr6-CpG: 44/Downstream/392597
Upstream sequence
ATATTCAGCCTTGTTTCTTGATAACATAGAGAGAAGTAAGGTTGTGAAGAAGAACCCCATGAGTTGGCATGAACCCCAAGAGTTAGTCACAGAGCTATGT
Downstream sequence
TAGTGAATTTCCAATTTCTTCCTCAATGGATTAGAACTTGGAACTCAAGTTGGAGTAATTGGGTTAAGGCTCTTCTCAGCCACTAGGAAACACTATTCCA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate