Basic Information
VIS ID
TVIS44022590
Fusion event
HTLV-1-LRRC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
53714439/53849641 (Hg38)
End
53714439/53849641 (Hg38)
Orient
+
Location type
Intronic
Target gene
LRRC1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-22-3p ; hsa-mir-125b-2-3p ; hsa-mir-432-3p ; hsa-mir-506-3p ; hsa-mir-1193 ; hsa-mir-3681-5p ; hsa-mir-3691-5p ; hsa-mir-5582-5p ; hsa-mir-6849-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-432-5p ; hsa-mir-127-5p ; hsa-mir-4635 ; hsa-mir-7843-3p ; hsa-mir-4282 ; hsa-mir-150-3p ; hsa-mir-101-3p ; hsa-mir-5579-5p ; hsa-mir-144-3p ; hsa-mir-3714 ; hsa-mir-3910 ; hsa-mir-2277-5p ; hsa-mir-2355-5p ; hsa-mir-4286 ; hsa-mir-4426 ; hsa-mir-4634 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-4681 ; hsa-mir-652-3p
Nearest miRNA
hsa-mir-10398/Upstream/572570; hsa-mir-10524/Downstream/3540491;
Nearest TSS
ENST00000381078/Upstream/54551; ENST00000490222/Downstream/69599;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/53467, chr6-CpG: 74/Downstream/996714
Upstream sequence
AGGTTGGATGGCATCTTTTTGTCAGGATGGTAACACCAACATGCTCGCACCACTGCAAACAGCGCTCTCCTCTTACTGAGCTAGAAAAGACAAATCTTGG
Downstream sequence
AAAGGGACTTGAGCCAAGAGGGAAAGAGGGAATGAAAAGCAGTACTAAGAACTGCAATTTGAAGATTAAATATAGAAATGGTATGATTCTTAAATTAGCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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