Basic Information
VIS ID
TVIS44022597
Fusion event
HTLV-1-PRIM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
57482129/60514382 (Hg38)
End
57482129/60514382 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRIM2
miRNAs that regulate target gene
hsa-mir-665 ; hsa-mir-887-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-4266 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6894-5p ; hsa-mir-7160-5p ; hsa-mir-202-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-7162-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-890
Nearest miRNA
hsa-mir-10398/Upstream/3124170; hsa-mir-10524/Downstream/10862578;
Nearest TSS
ENST00000381078/Upstream/2475916; ENST00000622616/Downstream/208766;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2552832, chr6-CpG: 45/Downstream/1771568
Upstream sequence
gaagccaagacctatgggttgcttgagcccacgagttcgagaccagcctgggtaacttggcaaaacccagtctctacaaaaaaatacaaaaattagccag
Downstream sequence
gcgtggacgcatgcacctgtagtgtcagctatgcaggaggctgaggtgggaggattgctggattgcttgaggccatggggactgagtgagccatgatcat
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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