Basic Information
VIS ID
TVIS44022611
Fusion event
HTLV-1-COL9A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
70976599/70266896 (Hg38)
End
70976599/70266896 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
COL9A1
miRNAs that regulate target gene
hsa-mir-1273h-3p ; hsa-mir-4771 ; hsa-mir-3166 ; hsa-mir-1324 ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-4789-3p ; hsa-mir-8485
Nearest miRNA
hsa-mir-10398/Upstream/12876684; hsa-mir-10524/Downstream/1110064;
Nearest TSS
ENST00000381078/Upstream/5818; ENST00000418403/Downstream/8282;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/399216, chr6-CpG: 61/Downstream/15441
Upstream sequence
CTTGAGTTTGGTACAGAAAGTGATCAGAAGGCTCATAAAGTGATCCTGCTTCCCTAAATCAGTGCCAATGTATTACTAAGAAATGAGTTATGTCACAAAG
Downstream sequence
AAAATTAATGCCTTAAATGACCTTAACAGCACCATGACTGCCATATATAATTAATATCAGTTTTACTTAATAGAAAAACACTGCTCTAGAATAATACACT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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