Basic Information
VIS ID
TVIS44022615
Fusion event
HTLV-1-KHDC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
74018997/73309274 (Hg38)
End
74018997/73309274 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
KHDC1
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-10398/Upstream/341521; hsa-mir-10524/Downstream/2119133;
Nearest TSS
ENST00000381078/Upstream/41223; ENST00000370367/Downstream/869;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/9541, chr6-CpG: 57/Downstream/431
Upstream sequence
ccgctttgagaTCAGCTCTCCTAGGGTATCTAAGTGACGGGGCAGACCCGCAAAAGAGATTTAGTGGAAGATGGCCCCCTAGAGGAGCTGGCCTGGGATT
Downstream sequence
CCTGGGACTTCTAAACCTACAGTGCACAAATGTCCTAGATTTTCCACCTTTGGTTGCTTCTAGCCACAATCTTCCTTCCCAACCACATCTTGCCCTTTCT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate