Basic Information
VIS ID
TVIS44022616
Fusion event
HTLV-1-CD109 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
74407277/73697554 (Hg38)
End
74407277/73697554 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA6D
Target gene
CD109
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-4482-3p ; hsa-mir-6807-5p ; hsa-mir-6751-3p ; hsa-mir-1199-5p ; hsa-mir-449b-3p ; hsa-mir-103a-2-5p ; hsa-mir-3124-3p ; hsa-mir-186-3p
Nearest miRNA
hsa-mir-10398/Upstream/729801; hsa-mir-10524/Downstream/1730853;
Nearest TSS
ENST00000381078/Upstream/1423; ENST00000474094/Downstream/95101;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1143, chr6-CpG: 28/Downstream/1387610
Upstream sequence
ATTGGGGTGGAGCTTCTGGAACACTGCCCTTCACAGGTGACTGTGAAGGCGGAGCTGCTCAAGACAGCATCAAACCTCACTGTCTCTGTCCTGGAAGCAG
Downstream sequence
AAGGAGTCTTTGAAAAAGGTAAGATAAACAGCATAAAGTCTTACCCTTCTGCAGTAATAACTGGAATATGTTAATAAGGTCATGTGTTAGGTAGtatagc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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