Basic Information
VIS ID
TVIS44022618
Fusion event
HTLV-1-IMPG1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
76646389/75936672 (Hg38)
End
76646389/75936672 (Hg38)
Orient
-
Location type
Intronic
Target gene
IMPG1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-6733-3p ; hsa-mir-1231 ; hsa-mir-5706 ; hsa-mir-4782-5p ; hsa-mir-1290 ; hsa-mir-876-5p ; hsa-mir-3167 ; hsa-mir-7114-3p ; hsa-mir-1180-5p ; hsa-mir-6839-5p ; hsa-mir-378j ; hsa-mir-5581-3p ; hsa-mir-670-3p ; hsa-mir-617
Nearest miRNA
hsa-mir-10398/Upstream/508199; hsa-mir-10524/Downstream/2602591;
Nearest TSS
ENST00000381078/Upstream/1623; ENST00000626131/Downstream/136006;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/187122, chr6-CpG: 132/Downstream/1525842
Upstream sequence
TTTCATTTCAGTTCTCCACCACTCTCAAGAAGCACCACCACAGCTGACTCTCAATAATCCTTTTTTGTGTGAGTGGATGTGTGAATACCCACACACATCT
Downstream sequence
TGCCCTGGATGTGAGGTTGAAGAATTGTCTCAGCTTTCAGCCATTATTATTATCTGCCAAACAGAGGTGTTCTGGATGGATTGGCACTAGGGTGGTGGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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