Basic Information
VIS ID
TVIS44022637
Fusion event
HTLV-1-EPHA7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
93975427/93265709 (Hg38)
End
93975427/93265709 (Hg38)
Orient
-
Location type
Intronic
Target gene
EPHA7
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-93-5p ; hsa-mir-455-3p ; hsa-mir-615-3p ; hsa-mir-331-3p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-548c-3p ; hsa-mir-590-3p ; hsa-mir-8061 ; hsa-mir-4775 ; hsa-mir-4760-5p ; hsa-mir-3934-3p ; hsa-mir-4330 ; hsa-mir-10b-3p ; hsa-mir-577 ; hsa-mir-6757-3p ; hsa-mir-141-3p ; hsa-mir-200a-3p
Nearest miRNA
hsa-mir-10398/Upstream/1743972; hsa-mir-1202/Downstream/4758822;
Nearest TSS
ENST00000381078/Upstream/195322; ENST00000424678/Downstream/153817;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/2654209, chr6-CpG: 92/Downstream/150845
Upstream sequence
TACAGACTTTATAAAATCATCAAGGACATATGAAACAATGAAAATGAATATTCCAATAAATGATCCAGTTGCAAATATCATAAAATACATAATGTCAAAC
Downstream sequence
TAATATAATTTGCTATCTCTGAAACAATCAAGAGCTGCAATCTTTAATTTAAGGCAGGATGGGAAATACCATTCCTTCTTGTTGATGGCAAGGGACTAGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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