Basic Information
VIS ID
TVIS44022647
Fusion event
HTLV-1-DOCK4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
111397685/111757629 (Hg38)
End
111397685/111757629 (Hg38)
Orient
-
Location type
Intronic
Target gene
DOCK4
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-21-5p ; hsa-mir-98-5p ; hsa-mir-1277-5p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-1273g-5p ; hsa-mir-203a-5p ; hsa-mir-5011-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-6837-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p
Nearest miRNA
hsa-mir-10525/Upstream/9286098; hsa-mir-10399/Downstream/2895716;
Nearest TSS
ENST00000635602/Upstream/17415; ENST00000452714/Downstream/26797;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/29020, chr7-CpG: 106/Downstream/448176
Upstream sequence
ATGATCATGGATCTTTTTAATACTATCCCATTGTTGTTTTCCAGTGGCCTCCTTGCCTTGATATTTAGCCCATCAAATCTCTGGGCACAAGGGACTGCTC
Downstream sequence
TTTATTCAATCCTGTCATAACTCTGCAAAACCTTCCCCTTCTGATCTCCTCTCGGTTGTGAATGATCCCTGGAAATACTTCGGGGAGTACTGGGAACTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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