Basic Information
VIS ID
TVIS44022650
Fusion event
HTLV-1-THSD7A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.3
Reference genome
GRCh37/hg19
Start
11466631/11427004 (Hg38)
End
11466631/11427004 (Hg38)
Orient
+
Location type
Intronic
Target gene
THSD7A
miRNAs that regulate target gene
hsa-mir-574-5p ; hsa-mir-448 ; hsa-mir-6867-5p ; hsa-mir-190a-3p ; hsa-mir-223-5p ; hsa-mir-5011-5p ; hsa-mir-586 ; hsa-mir-1277-5p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-3119 ; hsa-mir-3158-3p ; hsa-mir-532-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-584-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-3692-3p ; hsa-mir-5581-5p ; hsa-mir-4297 ; hsa-mir-153-5p ; hsa-mir-210-3p
Nearest miRNA
hsa-mir-339/Upstream/4359959; hsa-mir-10399/Downstream/6700216;
Nearest TSS
ENST00000635602/Upstream/20049; ENST00000442107/Downstream/116055;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/452743, chr7-CpG: 25/Downstream/404777
Upstream sequence
CAATGAGAAAATTAGATGGGCAGGATGGAGAAATCTTAGAAAATGGAGTTGACCTCACAATACATAGCATGGGAAATTGATATATGATGCAAATAACTTG
Downstream sequence
TGATCCAACTTGTCAATGTACTGTTGTCTATCAGTATATTTATAGATTGATCTATCCGTTGATTTACCTTAATCAGTTCATCTGTTTTGTAGAAAATGAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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