Basic Information
VIS ID
TVIS44022651
Fusion event
HTLV-1-FOXP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
113981572/114341517 (Hg38)
End
113981572/114341517 (Hg38)
Orient
+
Location type
Intronic
Target gene
FOXP2
miRNAs that regulate target gene
hsa-mir-95-5p ; hsa-mir-3613-3p ; hsa-mir-548p ; hsa-mir-4422 ; hsa-mir-6835-3p ; hsa-mir-190a-5p ; hsa-mir-1273h-3p ; hsa-mir-129-5p ; hsa-mir-2467-3p ; hsa-mir-3678-3p ; hsa-mir-3680-3p ; hsa-mir-450b-5p ; hsa-mir-507 ; hsa-mir-557 ; hsa-mir-6516-5p
Nearest miRNA
hsa-mir-10525/Upstream/11869986; hsa-mir-10399/Downstream/311828;
Nearest TSS
ENST00000635602/Upstream/53486; ENST00000462331/Downstream/72757;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/253777, chr7-CpG: 61/Downstream/580598
Upstream sequence
GATAGATAAATAGACATACAAAAAGAAGACAAGACAGATAAATTGATATCTCCAGGGTTGTTTAAAAACAAACAAAAAATCTAACAGCATGCCCAGGAGG
Downstream sequence
ATGATTTCCCTAATATGAACATCAAATGTGTTTAAAAATAATTCATTATTTAAACAAATGCCAGTAGGTGTTGATGGCCTATAACTACTAACTGTAGTAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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