Basic Information
VIS ID
TVIS44022667
Fusion event
HTLV-1-EXOC4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
133657231/133972478 (Hg38)
End
133657231/133972478 (Hg38)
Orient
-
Location type
Intronic
Target gene
EXOC4
miRNAs that regulate target gene
hsa-mir-33a-5p ; hsa-mir-877-3p ; hsa-mir-93-3p ; hsa-mir-3200-3p
Nearest miRNA
hsa-mir-10525/Upstream/681490; hsa-mir-10399/Downstream/1234516;
Nearest TSS
ENST00000635602/Upstream/42037; ENST00000480337/Downstream/25097;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/890142, chr7-CpG: 17/Downstream/154774
Upstream sequence
CGTCATCTGAAGTACAAAGCAAAGGTGTCTTTTCTTCTGAAAATGTGTTTCAGTGATTCTTGGACATACTTTAACTTTCTGGATTAGGGAGTTCGTTACT
Downstream sequence
TATCTTCCTTATCTTTTAAGTTGTTTTCTTAACTAATACAAATAGGTATAATGACATTATAACAAACTTAAAATATCAGAATTGCTTTATTAAGTTCAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate