Basic Information
VIS ID
TVIS44022672
Fusion event
HTLV-1-ETV1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
13947866/13908241 (Hg38)
End
13947866/13908241 (Hg38)
Orient
+
Location type
Intronic
Target gene
ETV1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-339/Upstream/6841196; hsa-mir-10399/Downstream/4218979;
Nearest TSS
ENST00000635602/Upstream/1743; ENST00000412014/Downstream/77248;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1220618, chr7-CpG: 18/Downstream/81512
Nearest cancer related gene
ETV1(OG, No orient, 0)
Upstream sequence
TTTCTTTCTTCTTGTTCTACATTACTTATAAAATACAAGGCAAATACTATCTTCCAAAAAATGTTTTATTAGTGTAAAATTGAAGAGTATTTAAAAGTCG
Downstream sequence
AAGGGAATAAATAATCAAGGCAGCTTGTTCCCTAAATATTAGTGTGACTTTGGCCTGTCAGATTATATTGTAATTCTGTCCATAATTTTGAGATATTTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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