Basic Information
VIS ID
TVIS44022675
Fusion event
HTLV-1-FMC1-LUC7L2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
139071279/139386533 (Hg38)
End
139071279/139386533 (Hg38)
Orient
-
Location type
Intronic
Target gene
FMC1-LUC7L2
miRNAs that regulate target gene
hsa-mir-4257 ; hsa-mir-6847-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-6507-5p ; hsa-mir-335-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-222-5p ; hsa-mir-4775 ; hsa-mir-6832-5p ; hsa-mir-4735-5p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936 ; hsa-mir-590-3p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-4284 ; hsa-mir-767-5p ; hsa-mir-4772-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-6887-3p ; hsa-mir-6837-5p ; hsa-mir-4685-5p ; hsa-mir-7113-5p ; hsa-mir-6823-5p ; hsa-mir-6890-3p ; hsa-mir-6513-3p ; hsa-mir-29b-2-5p ; hsa-mir-34b-3p ; hsa-mir-6509-5p
Nearest miRNA
hsa-mir-10399/Upstream/342376; hsa-mir-11400/Downstream/3087994;
Nearest TSS
ENST00000635602/Upstream/11329; ENST00000482860/Downstream/29592;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/25801, chr7-CpG: 130/Downstream/96201
Upstream sequence
tcactctgtcgtccaggctggagtgcagtggtgtgatcttggcttactgcaagctccgcctcccgggttcacaccattctcctggctcagcctccctagt
Downstream sequence
agctgggactacaggcgcctgccaccacacctggctaatttttttttcgtatttttagtagagacggggttaccgtgttagccaggatggtctcgatctc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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