Basic Information
VIS ID
TVIS44022688
Fusion event
HTLV-1-DNAJB6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q36.3
Reference genome
GRCh37/hg19
Start
157150057/157357363 (Hg38)
End
157150057/157357363 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
DNAJB6
miRNAs that regulate target gene
hsa-mir-106b-5p ; hsa-mir-34a-5p ; hsa-mir-3529-3p ; hsa-mir-138-5p ; hsa-mir-548e-5p ; hsa-mir-3152-3p ; hsa-mir-4694-5p ; hsa-mir-3591-5p ; hsa-mir-5581-3p ; hsa-mir-6872-3p ; hsa-mir-7978 ; hsa-mir-203a-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-429 ; hsa-mir-944 ; hsa-mir-432-5p ; hsa-mir-6813-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3686 ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-4724-5p ; hsa-mir-4999-3p ; hsa-let-7c-3p ; hsa-mir-142-3p ; hsa-mir-3177-5p ; hsa-mir-6131 ; hsa-mir-133a-5p ; hsa-mir-4280 ; hsa-mir-5689 ; hsa-mir-4756-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-4797-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-20a-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-106a-5p ; hsa-mir-526b-3p ; hsa-mir-93-5p ; hsa-mir-17-5p ; hsa-mir-4309 ; hsa-mir-3198
Nearest miRNA
hsa-mir-10399/Upstream/5923724; hsa-mir-153-2/Downstream/216973;
Nearest TSS
ENST00000635602/Upstream/17542; ENST00000486247/Downstream/1210;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/19751, chr7-CpG: 20/Downstream/42863
Upstream sequence
gtccttccttccgtccttccttccgtccttccttccttccttccttccttccttccttcctCGTTCCGTCGCCCGGGCTGGAGTCCGGTGGCATGggctg
Downstream sequence
gagtctggtggcacgatgtcagctcactgcagtctctgcctcctgggttcaagcaattctgcttcagcctcccgagtagctgggactacaggtgtgcacc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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