Basic Information
VIS ID
TVIS44022699
Fusion event
HTLV-1-JAZF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
27905798/27866179 (Hg38)
End
27905798/27866179 (Hg38)
Orient
-
Location type
Intronic
Target gene
JAZF1
miRNAs that regulate target gene
hsa-mir-31-5p ; hsa-mir-96-5p ; hsa-let-7e-5p ; hsa-let-7a-5p ; hsa-mir-8063 ; hsa-let-7c-3p ; hsa-mir-507 ; hsa-mir-557 ; hsa-mir-379-3p ; hsa-mir-4666a-5p ; hsa-mir-19b-3p ; hsa-mir-19a-3p ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-216b-3p ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-377-3p ; hsa-mir-5583-5p ; hsa-mir-3129-3p ; hsa-mir-5585-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-200c-3p
Nearest miRNA
hsa-mir-1183/Upstream/696616; hsa-mir-10399/Downstream/1814555;
Nearest TSS
ENST00000635602/Upstream/2099; ENST00000436758/Downstream/125877;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/125197, chr7-CpG: 144/Downstream/313232
Upstream sequence
CACAACCTCAGCTCGTCTTCATCGAGTGAGGGCAGCACTGCCGGCACTGAAAGGATGGTGCTCTGTGACACAGTGCACGTAGGCATTTGTATGTAGTATG
Downstream sequence
GATATTTTGTACTTAGTAATTTTGCTTACTTAACAGACACTACAATTTCTATATGATAAAATGAAAGGAGCCACAATGATGATAGGCCAGATTGCAATGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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