Basic Information
VIS ID
TVIS44022709
Fusion event
HTLV-1-POU6F2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
39480781/39441182 (Hg38)
End
39480781/39441182 (Hg38)
Orient
+
Location type
Intronic
Target gene
POU6F2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-505-5p ; hsa-mir-545-3p ; hsa-mir-3120-3p ; hsa-mir-7850-5p ; hsa-mir-3978 ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa
Nearest miRNA
hsa-mir-1183/Upstream/2521750; hsa-mir-10399/Downstream/3709713;
Nearest TSS
ENST00000635602/Upstream/34564; ENST00000426456/Downstream/23910;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/26490, chr7-CpG: 55/Downstream/124995
Nearest cancer related gene
POU6F2(TSG, No orient, 0)
Upstream sequence
tctgacctcaaggggcaccaacctgatgccagtaggatcactcctatatagggtgtctgacaacccctgttggagggactcactcagttgggtggcatgg
Downstream sequence
ggaacaggacctgttaaacgTGTAAAAGGTATTTTTAAAGCTTAGCTTTTTTTTTTTTTTCAAGAAAATAACTCTGATAGCACTACAGAGGTTGAACTGA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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