Basic Information
VIS ID
TVIS44022711
Fusion event
HTLV-1-CDK13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p14.1
Reference genome
GRCh37/hg19
Start
40127041/40087442 (Hg38)
End
40127041/40087442 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDK13
miRNAs that regulate target gene
hsa-mir-133b ; hsa-mir-29b-2-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-664a-3p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-8061 ; hsa-mir-4760-5p ; hsa-mir-6794-3p ; hsa-mir-376a-5p ; hsa-mir-372-5p ; hsa-mir-888-5p
Nearest miRNA
hsa-mir-1183/Upstream/3168010; hsa-mir-10399/Downstream/3063453;
Nearest TSS
ENST00000635602/Upstream/9028; ENST00000465643/Downstream/4805;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/135429, chr7-CpG: 109/Downstream/46840
Upstream sequence
atgttgcccaggctggtcttgaactcctgggctcaagcaatcctcccgtcttggcctccctaagcactgggattataggcgtgagccactgtgcctggcT
Downstream sequence
GGAAATGGCATATTTTTCTGCCTTCTTTTTCATGTCTTATTCAGTGTATGATGTACTATCATAAGAACTGACTTTGAAAGGTTGCACCAACAGCAATAGT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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