Basic Information
VIS ID
TVIS44022719
Fusion event
HTLV-1-ZPBP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
50128416/50088820 (Hg38)
End
50128416/50088820 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZPBP
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-607 ; hsa-mir-2053 ; hsa-mir-4795-3p ; hsa-mir-3671 ; hsa-mir-889-3p ; hsa-mir-569 ; hsa-mir-205-3p ; hsa-mir-5011-5p ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-1183/Upstream/5207020; hsa-mir-10399/Downstream/6866965;
Nearest TSS
ENST00000635602/Upstream/32396; ENST00000297001/Downstream/4412;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/312664, chr7-CpG: 42/Downstream/4156
Upstream sequence
atactaggatagctataaaaaaagaagatggataataacaatgtttaggatattggaaaatctgaaccctcatacattgctggtgtgaaagtaaaatagc
Downstream sequence
ttaggctctttaaaaaatagtttggcagctcctcaaaatattaaacatagagttactcataGGTAGAGAAGTgagtattatcccaccctaaaaaggaatg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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