Basic Information
VIS ID
TVIS44022723
Fusion event
HTLV-1-chr7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
55059187/54991494 (Hg38)
End
55059187/54991494 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7A
Nearest miRNA
hsa-mir-1183/Upstream/10109694; hsa-mir-10399/Downstream/1964291;
Nearest TSS
ENST00000635602/Upstream/231520; ENST00000459688/Downstream/27527;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/58098, chr7-CpG: 31/Downstream/13079
Nearby gene
EGFR(+27538) ;
Nearest cancer related gene
EGFR(OG, +27538) ;
Upstream sequence
GGCAATGGCCGCTGCTAGGAGCCAAGGGAACCACCAATGGCAGACGCACTAGTGATGCTGGTTCGGGAAGGGCTGCAACTCCAAGGGCCGCTGGGTGGAA
Downstream sequence
GGTGATGGCAGGCTTCCTGCCGCCAGCTCACATCAGGACAGCGTCCACCCATCGGGAGGCATCAAACACAGGCCATCCGGGACTTCCGTCTCTGCCAGAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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