Basic Information
VIS ID
TVIS44022730
Fusion event
HTLV-1-CYTH3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
6210660/6171029 (Hg38)
End
6210660/6171029 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
CYTH3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-320a ; hsa-mir-891a-3p ; hsa-mir-3688-5p ; hsa-mir-548au-3p ; hsa-mir-449a ; hsa-mir-449b-5p ; hsa-mir-34c-5p ; hsa-mir-34a-5p ; hsa-mir-6778-3p ; hsa-mir-1281
Nearest miRNA
hsa-mir-339/Upstream/459119; hsa-mir-10399/Downstream/895935;
Nearest TSS
ENST00000635602/Upstream/70; ENST00000473564/Downstream/787;
Nearest CpG islands
chr7-CpG: 65/Target, None/Upstream, None/Downstream
Upstream sequence
AGGCTGGTGTTGAGCATGATGATGGCGAATGACAGCACGTAGCACGTGTCTGCAACGAGTCCGGGGTGCTGGGCTCAGCCAGAACCTCCAGTGGACAGTG
Downstream sequence
GGACCCCGCGTGCTGGGGGCCCGCCTGCAAGAGGTGCCCGGCCCACAGGTCGTCCTCGCTCAGGGAAGGCAGGTCCCCAGGAACACACGCTGGGCTGTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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