Basic Information
VIS ID
TVIS44022740
Fusion event
HTLV-1-FAM86LP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
6979171/6939540 (Hg38)
End
6979171/6939540 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
FAM86LP
Nearest miRNA
hsa-mir-339/Upstream/1227630; hsa-mir-10399/Downstream/127424;
Nearest TSS
ENST00000635602/Upstream/112770; ENST00000467716/Downstream/217394;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/4208, chr7-CpG: 106/Downstream/242849
Nearby gene
CCZ1B(No orient, 113245)
Upstream sequence
CCAGGGCCTGGGAAGGACGGGGGCTCCAGCACGCAGGTGGCTATGCTGTCTGGCTACTGGGCGGACACTCCCCATAACTGACCTTTTTGATGAGTTCTGA
Downstream sequence
GAGAAAGCACCGGGCATACTTGACTGACGGCCGGTGCTTCACACACACAGGATGCTTCACAGTCTACCGCAAAGGACAGAACGTTGGTTGCTCGAGAGCC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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