Basic Information
VIS ID
TVIS44022746
Fusion event
HTLV-1-STX1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
73130451/73716121 (Hg38)
End
73130451/73716121 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
STX1A
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-1237-5p ; hsa-mir-1249-5p ; hsa-mir-128-1-5p ; hsa-mir-128-2-5p ; hsa-mir-1321 ; hsa-mir-149-3p ; hsa-mir-3154 ; hsa-mir-3919 ; hsa-mir-4419a ; hsa-mir-4488 ; hsa-mir-4510 ; hsa-mir-4641 ; hsa-mir-4697-5p ; hsa-mir-4728-5p ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-6130 ; hsa-mir-6133 ; hsa-mir-6770-5p ; hsa-mir-6781-5p ; hsa-mir-6785-5p ; hsa-mir-6797-5p ; hsa-mir-6804-5p ; hsa-mir-6846-5p ; hsa-mir-6848-5p ; hsa-mir-6883-5p ; hsa-mir-7160-3p ; hsa-mir-7515
Nearest miRNA
hsa-mir-1183/Upstream/4724; hsa-mir-10399/Downstream/475077;
Nearest TSS
ENST00000635602/Upstream/10241; ENST00000476494/Downstream/3505;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/32271, chr7-CpG: 58/Downstream/2937
Upstream sequence
tctgcccccacaggctgcatgacctcagataaacacctggccctttctggacctgttttctgatctgtaagataggaggttgaactagatggtcccggga
Downstream sequence
ggccgttccacctGCACCCCAGATGAAAATGTACCCAAATGCATCGTTCATGCTGGGAAACCTCTGGAACGTAATGGGAGGAAGGATCGGGCGAGCCCTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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