Basic Information
VIS ID
TVIS44022747
Fusion event
HTLV-1-DNAAF5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
781274/741637 (Hg38)
End
781274/741637 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
DNAAF5
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-let-7b-5p ; hsa-mir-1301-3p ; hsa-mir-615-3p ; hsa-mir-92b-3p ; hsa-mir-149-5p ; hsa-mir-31-5p
Nearest miRNA
hsa-mir-10399/Downstream/281296;
Nearest TSS
ENST00000635602/Upstream/13987; ENST00000491496/Downstream/22270;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/673, chr7-CpG: 25/Downstream/10710
Upstream sequence
AAGGAAGCTTCAGCTCTTGCAGTTCTGAGCCCAGGCGGCCGCGTCGGAAAGGTGCAGGCGTCTCCCCACTGGGCTGGGGCTCCTGCATCCTGGGCAGAGC
Downstream sequence
ACGTCTCTCCTCAGCATCTGGAGAGCCCCCATGTGCCTTGCAGTGACCTCTCCCCTCCTCTGGCCAGCTTTATTTTAAAAAGGCTGTGGGCTTCTGAAAG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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