Basic Information
VIS ID
TVIS44022748
Fusion event
HTLV-1-UPK3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
76144091/76514774 (Hg38)
End
76144091/76514774 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
UPK3B
Nearest miRNA
hsa-mir-10525/Upstream/599505; hsa-mir-10399/Downstream/15689241;
Nearest TSS
ENST00000635602/Upstream/3239; ENST00000415750/Downstream/25612;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/14470, chr7-CpG: 32/Downstream/1305
Upstream sequence
gtgggaggatcactggaggccaaaagttcaagaccagcctgagcaacatggtgaaaccccatctccactaaaaatgcaaaaattgtccgggtgtggtggc
Downstream sequence
aggcacctgtaatcccagctactcgggaggctgaggcaggagaatcgtttgaacccgggtggcgaaggttacagtgagcttagatcacaccaccgcactc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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