Basic Information
VIS ID
TVIS44022760
Fusion event
HTLV-1-TMEM243 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
86845852/87216536 (Hg38)
End
86845852/87216536 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM243
miRNAs that regulate target gene
hsa-mir-484
Nearest miRNA
hsa-mir-10525/Upstream/11301267; hsa-mir-10399/Downstream/4987479;
Nearest TSS
ENST00000635602/Upstream/13493; ENST00000412227/Downstream/385;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/63658, chr7-CpG: 114/Downstream/3059
Upstream sequence
cactgcctcaaagacaaaaaaaTCCCTTAGATATTTATGGAACAATAGAGAACTGTTTCACTTTGCCTTTCTCTCCATGACTATGTCTGTAAAGCTATTC
Downstream sequence
CTAAATAGGAATAACTTAGAATGAACAATTTTCATGCTAAAGATTGAACAAATTTCAGTAACTGAAATCACTATGTGCACTCAGCACCCATAAAGGCAAA
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate