Basic Information
VIS ID
TVIS44022777
Fusion event
HTLV-1-TRRAP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
98569301/98971678 (Hg38)
End
98569301/98971678 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
TRRAP
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-9-5p ; hsa-mir-30a-5p ; hsa-mir-1301-3p ; hsa-mir-1229-3p ; hsa-mir-760 ; hsa-mir-193b-3p ; hsa-mir-330-3p ; hsa-mir-106b-5p ; hsa-mir-185-5p ; hsa-mir-181b-5p ; hsa-mir-31-5p ; hsa-mir-23a-3p ; hsa-mir-17-5p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-10525/Upstream/89949; hsa-mir-10399/Downstream/437494;
Nearest TSS
ENST00000635602/Upstream/1491; ENST00000480695/Downstream/4282;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/16339, chr7-CpG: 18/Downstream/10138
Upstream sequence
GGTGGCTTCTTTATAGTCATTTTTAAAAAGAGAGCGATCTGGTCTAGTTAATCCAGGTTTTGTTTATTTTAGGATTGAAGATTATTTAAATACTTACACA
Downstream sequence
CTTCCAGGAAACGAACACGAATTTTACCAAAATTGTAACAAGAAGCCTACAGGAGGTGTGTTTGTTGGGTTTTCTTGAAGCCTTTGACCTTTTGGTTTTG
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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