Basic Information
VIS ID
TVIS44022780
Fusion event
HTLV-1-ZSCAN25 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99228168/99630545 (Hg38)
End
99228168/99630545 (Hg38)
Orient
+
Location type
UTR3
Fragile sites / regions
FRA7F
Target gene
ZSCAN25
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-6847-5p ; hsa-mir-6811-5p ; hsa-mir-6516-5p ; hsa-mir-7151-3p ; hsa-mir-6511b-5p ; hsa-mir-5095 ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-4438 ; hsa-mir-148a-5p ; hsa-mir-4762-3p ; hsa-mir-6866-5p ; hsa-mir-4303 ; hsa-mir-877-5p ; hsa-mir-3119 ; hsa-mir-3188 ; hsa-mir-4524a-3p ; hsa-mir-627-3p ; hsa-mir-6761-5p ; hsa-mir-4251 ; hsa-mir-4329 ; hsa-mir-374c-3p ; hsa-mir-4640-3p ; hsa-mir-3620-5p ; hsa-mir-1587 ; hsa-mir-4741 ; hsa-mir-4675 ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-6829-5p ; hsa-mir-4656 ; hsa-mir-1185-5p ; hsa-mir-1245b-3p ; hsa-mir-184 ; hsa-mir-3605-5p ; hsa-mir-3651 ; hsa-mir-3679-5p ; hsa-mir-4271 ; hsa-mir-4293 ; hsa-mir-4725-3p ; hsa-mir-4804-5p ; hsa-mir-5092 ; hsa-mir-5683 ; hsa-mir-596 ; hsa-mir-6780b-5p
Nearest miRNA
hsa-mir-10525/Upstream/221281; hsa-mir-10399/Downstream/463015;
Nearest TSS
ENST00000635602/Upstream/9484; ENST00000608397/Downstream/30057;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/13283, chr7-CpG: 76/Downstream/288434
Upstream sequence
acatttattgaacatcctctgagcacctggccgtgggaatgccgtggtgaatgagagactagacgtgatgcctCTGGGGGTTGTGCGTTGGGGATGCATG
Downstream sequence
CGACAGCCCATGACCCGAGGCATTCTCAGGGTATCTGTGCTGTGTGCCCGTGAGAACATCTTCCCATGACCACTCCTGCCCTCCTGCCCCGTGCTGGATC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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