Basic Information
VIS ID
TVIS44022789
Fusion event
HTLV-1-DCAF13 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
104431726/103419498 (Hg38)
End
104431726/103419498 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
DCAF13
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-149-5p
Nearest miRNA
hsa-mir-12123/Upstream/264809; hsa-mir-10400/Downstream/1064871;
Nearest TSS
ENST00000518652/Upstream/4086; ENST00000611541/Downstream/19984;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/3903, chr8-CpG: 243/Downstream/79329
Upstream sequence
gtttttggaacagcgcctggcacTTGAACTCTTATGTGAGTCTTTTTTAAGTAAGTAAACAAacatagaaagtgctcagtaaatgatagctatataatAT
Downstream sequence
CATCATAATCACAACTTCGTGTGTCTATCAGCACAGTATTTAGCACcagagattaataatgttccctgccctacaggaagcttagagttctgttgagcaa
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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