Basic Information
VIS ID
TVIS44022790
Fusion event
HTLV-1-RIMS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
104951243/103939015 (Hg38)
End
104951243/103939015 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8A
Target gene
RIMS2
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-335-3p ; hsa-mir-376b-3p ; hsa-mir-376a-3p ; hsa-mir-3065-3p
Nearest miRNA
hsa-mir-12123/Upstream/784326; hsa-mir-10400/Downstream/545354;
Nearest TSS
ENST00000518652/Upstream/23502; ENST00000523362/Downstream/284320;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/437330, chr8-CpG: 51/Downstream/284141
Upstream sequence
gctgatgcaagaggtgggttcccatggtcttgggcagctctacccctgtggctttgcagagtataacccccctcctggctgctttcatgggctggcgctg
Downstream sequence
agtgtctgttggtttcccaggtgcacagtgcaagctgtagatggatctaccattctggggtctggaggttggtggccatcttctcacagctccactaggt
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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