Basic Information
VIS ID
TVIS44022793
Fusion event
HTLV-1-OXR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
107746298/106734070 (Hg38)
End
107746298/106734070 (Hg38)
Orient
+
Location type
Intronic
Target gene
OXR1
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-200b-3p ; hsa-mir-567 ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-4781-3p ; hsa-mir-144-3p ; hsa-mir-3144-3p ; hsa-mir-3915 ; hsa-mir-6730-3p ; hsa-mir-4689 ; hsa-mir-6858-5p ; hsa-mir-1224-5p ; hsa-mir-3928-3p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-586 ; hsa-mir-875-5p
Nearest miRNA
hsa-mir-12123/Upstream/2249605; hsa-mir-10400/Downstream/5909423;
Nearest TSS
ENST00000518652/Upstream/7885; ENST00000521864/Downstream/6173;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/75707, chr8-CpG: 92/Downstream/1348557
Upstream sequence
TAATAGAATTAATTCTGGAtttttttttttttttttttaagacaggattttgctctgttgcccaggatggagtgcagtggcttgatcttggctcactgca
Downstream sequence
gcctcaacctgctgggctcaggtgatccttccacgccaccaggcccggctaattttttgtatttttttgtagagacgagatttctccatgttgccccggc
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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