Basic Information
VIS ID
TVIS44022803
Fusion event
HTLV-1-PVT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
128853375/127841129 (Hg38)
End
128853375/127841129 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
PVT1
miRNAs that regulate target gene
hsa-mir-186-5p
Nearest miRNA
hsa-mir-1204/Upstream/45101; hsa-mir-10400/Downstream/119504;
Nearest TSS
ENST00000518652/Upstream/45096; ENST00000615442/Downstream/13599;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/46476, chr8-CpG: 18/Downstream/8582
Nearest cancer related gene
PVT1(OG, No orient, 0)
Upstream sequence
AAAGCTTGCTCCGGGAATCGATGGTTTGGGAAACAATGCTTGCTGtctttgagtcctcagtcctgtaaaatggggaaagtatacatcagagggcatttga
Downstream sequence
gagtaaggcaagaagcgcttggcatgtgcctggcacatagtacctgttcagcagatTCCCTTTCAGCTCAGGGTTAGATCTTCATCCACCTCTTGTTGGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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