Basic Information
VIS ID
TVIS44022806
Fusion event
HTLV-1-ST3GAL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
134505237/133492994 (Hg38)
End
134505237/133492994 (Hg38)
Orient
+
Location type
Intronic
Target gene
ST3GAL1
miRNAs that regulate target gene
hsa-mir-204-5p ; hsa-mir-6823-5p ; hsa-mir-451b ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-642a-5p ; hsa-mir-1248 ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-5698 ; hsa-mir-744-3p ; hsa-mir-6794-3p ; hsa-mir-4423-5p ; hsa-mir-6501-5p ; hsa-mir-143-5p ; hsa-mir-3650 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-122-5p ; hsa-mir-504-3p ; hsa-mir-3135b ; hsa-mir-6499-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-1304-3p ; hsa-mir-4639-3p ; hsa-mir-3664-5p ; hsa-mir-4701-5p
Nearest miRNA
hsa-mir-1204/Upstream/446413; hsa-mir-10400/Downstream/1307526;
Nearest TSS
ENST00000518652/Upstream/3294; ENST00000561761/Downstream/6367;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/195092, chr8-CpG: 249/Downstream/76732
Upstream sequence
CTCTCCCCACAAAGTGATCACGAGTGCTCCTCACCCTCCGTCCAATAAGGAGGCGACTCTGGCAGGAGAGATAAACTGAGCTACGCCGAATGACCGCTGG
Downstream sequence
GAATGGCCAAACACCCTCATGGCCAGAGGTGCTAGAGACAGCTCTGTCCCAGCTCTGTCTGAGCTGGCCACCAGGTAGGCATCCAACACTGGGAGTGTGC
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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