Basic Information
VIS ID
TVIS44022807
Fusion event
HTLV-1-ZFAT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
135519615/134507372 (Hg38)
End
135519615/134507372 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZFAT
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1204/Upstream/1460791; hsa-mir-10400/Downstream/293148;
Nearest TSS
ENST00000518652/Upstream/186925; ENST00000505776/Downstream/2810;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/28529, chr8-CpG: 82/Downstream/205155
Upstream sequence
AATTCAGAGGGCATCCTTTCACCTGGGAGAGCCTGAAACACTTCATTTCCTTTGCTATAGGAGTGGTGCTCAGCGTCTACCCGCCCATCAGTCTGTCCAC
Downstream sequence
CCACTCTCCTCTCTGTCATTTATCAACAGCCACCGTGAGCGAGGTGCGGGGCCAGGCAGACAAGATAATGGCCAGGACATACACCTTCTTGGGGAACATT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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