Basic Information
VIS ID
TVIS44022818
Fusion event
HTLV-1-DENND3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
142139066/141128967 (Hg38)
End
142139066/141128967 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA8D
Target gene
DENND3
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1204/Upstream/396314; hsa-mir-10400/Downstream/657275;
Nearest TSS
ENST00000518652/Upstream/188; ENST00000518249/Downstream/994;
Nearest CpG islands
chr8-CpG: 99/Target, None/Upstream, None/Downstream
Upstream sequence
TCGGAGAGCGGGCGCCCGGGTGCCCTGTGGGTTGGCGCGGACTTTCCGAGGGCTGAGTCCCGGTCCCCCGGCGGTGACCCCGCGCGCCTGTGGCCGGGGA
Downstream sequence
TCGCGCCCGAGCTCAGGCAGGTGCCCTGGAGCAGCGCCCTGCTCCCCTCCCCTCTTCTCTCCTCTCCCCGCCCGGGGCCCTTGGTGTGAGACATGTCTTT
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
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