Basic Information
VIS ID
TVIS44022823
Fusion event
HTLV-1-DLGAP2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP)
Quality evaluation
Normal
Reported year
2017
PubMed ID
29186194
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p23.3
Reference genome
GRCh37/hg19
Start
1372927/1424761 (Hg38)
End
1372927/1424761 (Hg38)
Orient
+
Location type
Intronic
Target gene
DLGAP2
miRNAs that regulate target gene
hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-20a-3p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-4764-5p ; hsa-mir-627-3p ; hsa-mir-4635
Nearest miRNA
hsa-mir-10400/Downstream/376364;
Nearest TSS
ENST00000518652/Upstream/46894; ENST00000522499/Downstream/76605;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/7424, chr8-CpG: 31/Downstream/12278
Nearby gene
DLGAP2(+76605) ;
Upstream sequence
TCCCCTTACACACAGCACCTGGAGGAGTCAGATGCACAGACAGAAGGCCGGATAGGACAAGGATGGTGTGATCCCCTTACACGCAGCACCTGGAGAAGTC
Downstream sequence
AGATGCACAGACAGAAGGCCGaataggacaaggacagtatgatccccttatacgcagcacctggaggagttggatacacagacaggtcagagggaggctg
Reference
Furuta, R., et al.Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo. PLoS Pathog,2017,13(11): e1006722.
Curate